منابع مشابه
Evaluation of serum s-IgE/total IgE ratio in predicting clinical response to allergen-specific immunotherapy.
BACKGROUND To date, no predictive tests for the clinical response to allergen-specific immunotherapy (ASI) are available. Therefore an in vivo or in vitro test would be of great value. OBJECTIVE We sought to evaluate pretreatment parameters used in diagnosing allergic rhinitis and determining serum specific IgE (s-IgE) levels, serum total IgE (t-IgE) levels, and blood eosinophil counts and to...
متن کاملSerum specific IgE: biomarker for specific immunotherapy responsiveness?
Specific immunotherapy (SIT) is at present the only causal treatment for allergic disorders. Successful SIT is capable of inducing a physiological immune tolerance towards the causal allergen. The mechanism of action is still not completely known, however a restoring of T regulatory cells and a T helper 1 repolarisation are associated with clinical improvement after SIT. Many double-blind place...
متن کاملOral immunotherapy and anti-IgE antibody treatment for food allergy
Food allergy is a major public health problem affecting nearly 10 % of children in most industrialized countries. Unfortunately, there are no effective therapies for food allergy, relegating patients to simply avoid the offending foods and treat reactions that occur on accidental exposure. Recently however, studies suggest that food immunotherapy may provide a promising new approach to food all...
متن کاملEAACI Guidelines on allergen immunotherapy: IgE-mediated food allergy.
Food allergy can result in considerable morbidity, impairment of quality of life, and healthcare expenditure. There is therefore interest in novel strategies for its treatment, particularly food allergen immunotherapy (FA-AIT) through the oral (OIT), sublingual (SLIT), or epicutaneous (EPIT) routes. This Guideline, prepared by the European Academy of Allergy and Clinical Immunology (EAACI) Task...
متن کاملSerum specific IgE: a biomarker of response to allergen immunotherapy.
BACKGROUND Allergen immunotherapy (AIT) has proven to be effective. However, no biomarkers capable of predicting the clinical response to AIT have been detected. The aim of the present study was to determine a cutoff value for serum specific IgE that could be associated with effective AIT. METHODS We evaluated 174 allergic patients (83 males) with ages ranging between 6 and 77 years. All pati...
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ژورنال
عنوان ژورنال: mAbs
سال: 2013
ISSN: 1942-0870,1942-0862
DOI: 10.4161/mabs.27029